New Treatments for Malaria Targeting Both the Sexual and Asexual Stages of the Causative Parasite, Plasmodium Falciparumnew Treatments for Malaria Targeting Both the Sexual and Asexual Stages of the Causative Parasite, Plasmodium Falciparum

Grant number: 1102147 | Funding period: 2016 - 2018

Completed

Abstract

We have discovered a potent antimalarial compound class. In this research plan we will improve their metabolic stability such that we can progress them as potential oral cures for malaria. We will also elucidate their mechanism of action and this will aid therapeutic development.

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3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

L Xue, DH Shi, JR Harjani, F Huang, JG Beveridge, T Dingjan, K Ban, S Diab, S Duffy, L Lucantoni, S Fletcher, FCK Chiu, S Blundell, K Ellis, SA Ralph, G Wirjanata, S Teguh, R Noviyanti, M Chavchich, D Creek

2019-03-14

A series of 3,3′-disubstituted 5,5′-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of ..

Synthesis of 3-(Alkylamino)-, 3-(Alkoxy)-, 3-(Aryloxy)-, 3-(Alkylthio)-, and 3-(Arylthio)-1,2,4-triazines by Using a Unified Route with 3-(Methylsulfonyl)-1,2,4-triazine

DH Shi, JR Harjani, RW Gable, JB Baell

2016-06-01

In our attempts to synthesize 3-(alkylthio)- and 3-(alkoxy)-1,2,4-triazines without substituents at the 5- or 6-position, the synt..

University of Melbourne Researchers

Stuart Ralph